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What are norepinephrine and dopamine reuptake inhibitors (NDRIs) for depression?

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Norepinephrine and dopamine reuptake inhibitors (NDRIs) affect norepinephrine and a different chemical in the brain, dopamine. This class of drugs includes bupropion (Wellbutrin). Side effects are usually mild, and include upset stomach, headache, sleep problems, tremor, and anxiety. Wellbutrin may be less likely to cause sexual side effects or weight gain than other antidepressants.

Reviewed by Smitha Bhandari on June 27, 2019
Reviewed by Smitha Bhandari on June 27, 2019

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How can norepinephrine and dopamine reuptake inhibitors (NDRIs) help with depression?

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