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What brain chemistry is involved in antidepressants?

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You may have heard depression described as a "chemical imbalance" or a "serotonin deficiency." We don’t really know what causes depression or how it affects the brain, or how exactly antidepressant medication helps. Many researcher think antidepressants work by affecting certain brain circuits and chemicals called neurotransmitters. These chemicals include serotonin, dopamine, and norepinephrine. Antidepressants may work by changing how these chemical behave.

SOURCES:

News release, FDA.

Ian A. Cook, MD, director of the Depression Research Program, University of California Los Angeles.

Dean F. MacKinnon, MD, associate professor, the Johns Hopkins Hospital, Baltimore.

MedicineNet, "Antidepressants."

Medscape: “FDA Approvals: Symbyax and Edluar.”

National Institute of Mental Health Web site, "Depression."

Reviewed by Smitha Bhandari on June 27, 2019

SOURCES:

News release, FDA.

Ian A. Cook, MD, director of the Depression Research Program, University of California Los Angeles.

Dean F. MacKinnon, MD, associate professor, the Johns Hopkins Hospital, Baltimore.

MedicineNet, "Antidepressants."

Medscape: “FDA Approvals: Symbyax and Edluar.”

National Institute of Mental Health Web site, "Depression."

Reviewed by Smitha Bhandari on June 27, 2019

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