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What causes treatment-resistant depression?

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Many things can make your depression hard to treat:

  • Quitting antidepressants before they have time to work.
  • Skipping doses.
  • Bad side effects that make you stop taking your meds.
  • Drug interactions. Some meds can keep your antidepressants from working well.
  • The wrong medicine or the wrong dose.
  • You may have genes that are linked with harder-to-treat forms of depression.
  • You have heart disease, cancer, thyroid problems, or other conditions that may play a role in your depression.
  • Substance abuse.
  • Misdiagnosis. You may have bipolar disorder or another type of mood disorder.

From: Treatment-Resistant Depression WebMD Medical Reference

SOURCES:

American Psychiatric Association, , 2000. Practice Guideline for the Treatment of Patients with Major Depression

American Psychological Association, , 4th edition, Text Revision, 2000. Diagnostic and Statistical Manual of Mental Disorders

Cadieux, R.J. , December 1998. American Family Physician

Depression and Bipolar Support Alliance: "Treatment Challenges: Finding Your Way To Wellness."

Fochtmann, L.J. and Gelenberg, A.J., , Winter, 2005. Focus

Keller, M.B., , 2005. Journal of Clinical Psychiatry

National Institute of Mental Health, Press Release, "Mutant Gene Linked To Treatment Resistant Depression."

National Mental Health Association: "Depression: What You Need To Know."

Stimmel, G. , July 2002. Psychiatric Times

Reviewed by Joseph Goldberg on October 16, 2018

SOURCES:

American Psychiatric Association, , 2000. Practice Guideline for the Treatment of Patients with Major Depression

American Psychological Association, , 4th edition, Text Revision, 2000. Diagnostic and Statistical Manual of Mental Disorders

Cadieux, R.J. , December 1998. American Family Physician

Depression and Bipolar Support Alliance: "Treatment Challenges: Finding Your Way To Wellness."

Fochtmann, L.J. and Gelenberg, A.J., , Winter, 2005. Focus

Keller, M.B., , 2005. Journal of Clinical Psychiatry

National Institute of Mental Health, Press Release, "Mutant Gene Linked To Treatment Resistant Depression."

National Mental Health Association: "Depression: What You Need To Know."

Stimmel, G. , July 2002. Psychiatric Times

Reviewed by Joseph Goldberg on October 16, 2018

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