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Which antidepressants are most likely to lead to discontinuation symptoms?

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Discontinuation symptoms are more likely with antidepressants that stay in your body for a shorter period of time, especially those that affect both serotonin and norepinephrine, such as Effexor (venlafaxine) and Cymbalta (duloxetine). Other short-acting medications that affect mainly serotonin include:

  • Celexa (citalopram)
  • Lexapro (escitalopram)
  • Paxil (paroxetine)
  • Zoloft (sertraline)

SOURCES:

American Medical Association web site: “American Medical News: The Long Goodbye: The Challenge of Discontinuing Antidepressants."

American Family Physician web site: "Antidepressant Discontinuation Syndrome."

FDA web site: “Understanding Antidepressant Medications.”

Marx, J. , 7th ed. Rosen’s Emergency Medicine

Shelton, R. , 2006. The Journal of Clinical Psychiatry

Mayo Clinic.org web site: “Symptoms from Antidepressant Withdrawal Can Be Reduced by Tapering.”

Haddad, P. , 2007. Advances in Psychiatric Treatment

Help Guide.org web site. “Antidepressants: What You Need to Know About Depression Medications.” 

Andrade, C. , July 2004. Journal of Clinical Psychiatry

Warner, C. , August 2006. American Family Physician

 

Reviewed by Joseph Goldberg on February 11, 2017

SOURCES:

American Medical Association web site: “American Medical News: The Long Goodbye: The Challenge of Discontinuing Antidepressants."

American Family Physician web site: "Antidepressant Discontinuation Syndrome."

FDA web site: “Understanding Antidepressant Medications.”

Marx, J. , 7th ed. Rosen’s Emergency Medicine

Shelton, R. , 2006. The Journal of Clinical Psychiatry

Mayo Clinic.org web site: “Symptoms from Antidepressant Withdrawal Can Be Reduced by Tapering.”

Haddad, P. , 2007. Advances in Psychiatric Treatment

Help Guide.org web site. “Antidepressants: What You Need to Know About Depression Medications.” 

Andrade, C. , July 2004. Journal of Clinical Psychiatry

Warner, C. , August 2006. American Family Physician

 

Reviewed by Joseph Goldberg on February 11, 2017

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Can long-acting antidepressants can lead to discontinuation symptoms?

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