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What are the side effects of exenatide (Bydureon, Byetta)?

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The most common side effects of exenatide include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. These symptoms usually go away after the first month of treatment. Inflammation of the pancreas (pancreatitis), which may be severe, is another side effect.

The FDA has also received reports of kidney failure in people taking this drug. All GLP-1 drugs, including both types of exenatide, have a boxed warning noting that in animal studies this type of drug has been linked to thyroid cancer in some rats and mice. Experts don't know whether it has the same effect in people. It's possible you could get low blood sugar or have an allergic reaction to the drug.

SOURCES:

Nathan D. Diabetes Care, January 2009. 

Chiara Rossi M. Acta Biomed. 2009.

American Diabetes Association: "Other Injectable Medications."

Jones M. American Family Physician. June 2007.

UC Davis Health System: "Other injectable medications for diabetes."

Parks M. New England Journal of Medicine, 2010.

Meade L. Journal of Pharmacy Practice, December 2009.

FDA: "Byetta (exenatide) -- Renal Failure."

UpToDate: “Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes mellitus

Trulicty web site.

Reviewed by Jennifer Robinson on January 21, 2020

SOURCES:

Nathan D. Diabetes Care, January 2009. 

Chiara Rossi M. Acta Biomed. 2009.

American Diabetes Association: "Other Injectable Medications."

Jones M. American Family Physician. June 2007.

UC Davis Health System: "Other injectable medications for diabetes."

Parks M. New England Journal of Medicine, 2010.

Meade L. Journal of Pharmacy Practice, December 2009.

FDA: "Byetta (exenatide) -- Renal Failure."

UpToDate: “Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes mellitus

Trulicty web site.

Reviewed by Jennifer Robinson on January 21, 2020

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