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What causes higher levels of inflammatory chemicals and the development of diabetes?

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How could carrying extra weight and sofa-sitting be connected to higher levels of inflammatory chemicals in the body and the development of diabetes?

Researchers discovered that in people with type 2 diabetes, cytokine levels are elevated inside fat tissue. They concluded that excess body fat, especially in the abdomen, causes continuous, yet low levels of abnormal inflammation that alters insulin's action and contributes to the disease.

As type 2 diabetes starts to develop, the body becomes less sensitive to insulin and the resulting insulin resistance also leads to inflammation. A vicious cycle can result, with more inflammation causing more insulin resistance and vice versa. Blood sugar levels creep higher and higher, eventually resulting in type 2 diabetes.

Emotional stress can also increase levels of the chemicals of inflammation. It's unknown whether stress by itself can contribute to the development of diabetes, though.

From: Diabetes and Inflammation WebMD Medical Reference

SOURCES:

Wenner, M. , December 2009. Scientific American Magazine

Hopps, E. , 2011; vol 48: pp 183-189. Acta Diabetologica

Hardy, O. , 2012; vol 18: pp 81-87. Current Opinion in Endocrinology, Diabetes, and Obesity

Reviewed by Michael Dansinger on June 22, 2019

SOURCES:

Wenner, M. , December 2009. Scientific American Magazine

Hopps, E. , 2011; vol 48: pp 183-189. Acta Diabetologica

Hardy, O. , 2012; vol 18: pp 81-87. Current Opinion in Endocrinology, Diabetes, and Obesity

Reviewed by Michael Dansinger on June 22, 2019

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