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What drugs can interact with sulfonylureas for diabetes?

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About 100 drugs can change the way sulfonylureas work. They include:

  • Azole antifungals, including fluconazole and ketoconazole 
  • Some antibiotics, such as chloramphenicol, ciprofloxacin, clarithromycin (Biaxin), isoniazid (Nydrazid), rifampin, and sulfasalazine (Azulfidine, Azulfidine Entabs, Gantrisin Pediatric, Sulfazine, Sulfazine EC, co-trimoxazole, Zonegran)
  • Cholesterol-lowering drugs, such as clofibrate and gemfibrozil
  • Tricyclic antidepressants
  • H2 blockers
  • Gout medications, such as probenecid 
  • Some high blood pressure medicines, including ACE inhibitors and bosentan
  • Beta-blockers
  • Corticosteroids
  • Calcium channel blockers
  • Oral contraceptives
  • Thiazide diuretics
  • Thyroid medicines

SOURCES:

Norman Tomaka, PharmD, media liaison, American Pharmacists Association.

National Institute of Diabetes and Digestive and Kidney Diseases: "Insulin, Medicines & Other Diabetes Treatments."

FDA: "Drug Interactions: What You Should Know," "Humalog: Highlights of Prescribing Information."

Mayo Clinic: "Type 2 Diabetes."

Joslin Diabetes Center: "Oral Diabetes Medications Summary Chart."

American Diabetes Association: "What Are My Options?"

Cleveland Clinic: "Oral Diabetes Medications."

Joslin Diabetes Center: "Sulfonylurea Agents: Oral Hypoglycemic Agents."

Archives of Medical Science : "Sulfonylureas and Their Use in Clinical Practice."

Expert Opinion on Drug Safety : "How Safe Is the Use of Thiazolidinediones in Clinical Practice?"

Diabetes Spectrum : "Drug Interactions of Medications Commonly Used in Diabetes."

Therapeutic Advances in Endocrinology and Metabolism : "Clinical and Pharmacologically Relevant Interactions of Antidiabetic Drugs."

Southern Medical Journal : "Medication Update."

Pharmacy & Therapeutics : "Sodium-Glucose Linked Transporter 2 (SGLT2) Inhibitors in the Management of Type-2 Diabetes: A Drug Class Overview."

Reviewed by Jennifer Robinson on April 25, 2020

SOURCES:

Norman Tomaka, PharmD, media liaison, American Pharmacists Association.

National Institute of Diabetes and Digestive and Kidney Diseases: "Insulin, Medicines & Other Diabetes Treatments."

FDA: "Drug Interactions: What You Should Know," "Humalog: Highlights of Prescribing Information."

Mayo Clinic: "Type 2 Diabetes."

Joslin Diabetes Center: "Oral Diabetes Medications Summary Chart."

American Diabetes Association: "What Are My Options?"

Cleveland Clinic: "Oral Diabetes Medications."

Joslin Diabetes Center: "Sulfonylurea Agents: Oral Hypoglycemic Agents."

Archives of Medical Science : "Sulfonylureas and Their Use in Clinical Practice."

Expert Opinion on Drug Safety : "How Safe Is the Use of Thiazolidinediones in Clinical Practice?"

Diabetes Spectrum : "Drug Interactions of Medications Commonly Used in Diabetes."

Therapeutic Advances in Endocrinology and Metabolism : "Clinical and Pharmacologically Relevant Interactions of Antidiabetic Drugs."

Southern Medical Journal : "Medication Update."

Pharmacy & Therapeutics : "Sodium-Glucose Linked Transporter 2 (SGLT2) Inhibitors in the Management of Type-2 Diabetes: A Drug Class Overview."

Reviewed by Jennifer Robinson on April 25, 2020

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