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What drugs can interact with sulfonylureas for diabetes?

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About 100 drugs can change the way sulfonylureas work. Some can make them work too well, which may lead to dangerously low blood sugar. Others may cause the medication to be less effective. Your doctor may need to keep tabs on your blood sugar or adjust your sulfonylurea dose.

The medicines that may affect how sulfonylureas work include:

  • Azole antifungals, including ketoconazole and fluconazole
  • Some antibiotics, such as ciprofloxacin, chloramphenicol, sulfonamide, clarithromycin, rifampin, and isoniazid
  • Cholesterol-lowering drugs, such as gemfibrozil, clofibrate
  • Tricyclic antidepressants
  • H2 blockers
  • Gout medications, such as sulfinpyrazone and probenecid
  • Some high blood pressure medicines, including ACE inhibitors and bosentan
  • Beta-blockers
  • Corticosteroids
  • Calcium channel blockers
  • Oral contraceptives
  • Thiazide diuretics
  • Thyroid medicines

SOURCES:

Norman Tomaka, PharmD, media liaison, American Pharmacists Association.

National Institute of Diabetes and Digestive and Kidney Diseases: "Insulin, Medicines & Other Diabetes Treatments."

FDA: "Drug Interactions: What You Should Know," "Humalog: Highlights of Prescribing Information."

Mayo Clinic: "Type 2 Diabetes."

Joslin Diabetes Center: "Oral Diabetes Medications Summary Chart."

American Diabetes Association: "What Are My Options?"

Cleveland Clinic: "Oral Diabetes Medications."

Joslin Diabetes Center: "Sulfonylurea Agents: Oral Hypoglycemic Agents."

Archives of Medical Science : "Sulfonylureas and Their Use in Clinical Practice."

Expert Opinion on Drug Safety : "How Safe Is the Use of Thiazolidinediones in Clinical Practice?"

Diabetes Spectrum : "Drug Interactions of Medications Commonly Used in Diabetes."

Therapeutic Advances in Endocrinology and Metabolism : "Clinical and Pharmacologically Relevant Interactions of Antidiabetic Drugs."

Southern Medical Journal : "Medication Update."

Pharmacy & Therapeutics : "Sodium-Glucose Linked Transporter 2 (SGLT2) Inhibitors in the Management of Type-2 Diabetes: A Drug Class Overview."

Reviewed by Michael Dansinger on June 22, 2019

SOURCES:

Norman Tomaka, PharmD, media liaison, American Pharmacists Association.

National Institute of Diabetes and Digestive and Kidney Diseases: "Insulin, Medicines & Other Diabetes Treatments."

FDA: "Drug Interactions: What You Should Know," "Humalog: Highlights of Prescribing Information."

Mayo Clinic: "Type 2 Diabetes."

Joslin Diabetes Center: "Oral Diabetes Medications Summary Chart."

American Diabetes Association: "What Are My Options?"

Cleveland Clinic: "Oral Diabetes Medications."

Joslin Diabetes Center: "Sulfonylurea Agents: Oral Hypoglycemic Agents."

Archives of Medical Science : "Sulfonylureas and Their Use in Clinical Practice."

Expert Opinion on Drug Safety : "How Safe Is the Use of Thiazolidinediones in Clinical Practice?"

Diabetes Spectrum : "Drug Interactions of Medications Commonly Used in Diabetes."

Therapeutic Advances in Endocrinology and Metabolism : "Clinical and Pharmacologically Relevant Interactions of Antidiabetic Drugs."

Southern Medical Journal : "Medication Update."

Pharmacy & Therapeutics : "Sodium-Glucose Linked Transporter 2 (SGLT2) Inhibitors in the Management of Type-2 Diabetes: A Drug Class Overview."

Reviewed by Michael Dansinger on June 22, 2019

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What are the side effects of meglitinides for diabetes?

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