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What is leptin and how is it related to lipodystrophy?

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Leptin tells your body you've eaten enough and to make insulin. Because fat tissue makes the hormone leptin, people with larger areas of acquired lipodystrophy might not have enough of this chemical in their bodies. Fat could also build up in places it shouldn't, like the blood, heart, liver, and kidneys. Depending on which type of lipodystrophy a person has, it may cause other problems, including diabetes, high cholesterol and triglycerides, liver disease, and kidney failure.  Doctors can help you manage these complications. 

SOURCES:

Orphanet: "Acquired generalized lipodystrophy," "Partial acquired lipodystrophy."

Medscape: "Localized Lipodystrophy."

FDA: "FDA approves Myalept to treat rare metabolic disease."

Lipodystrophy United: "About Lipodystrophy."

NORD Physician Guides: "Acquired Lipodystrophies."

University of Texas Southwestern Medical Center: "Lipodystrophy," "Lipodystrophy Therapies," "Acquired: Generalized Lipodystrophy (AGL; Lawrence Syndrome)," "Acquired: Partial Lipodystrophy (Barraquer-Simons Syndrome)," "Acquired: Localized."

KidsHealth: "Acanthosis Nigricans."

AACE Lipodystrophy Detection Consensus Statement, , January-February 2013. Endocrine Practice

Endocrine Society, Resource Room Slide Series: "Lipodystrophy: Metabolic and Clinical Aspects."

DermNet NZ: "Lipodystrophy."

Kumar, R. , January 2000. Indian Pediatrics

Reviewed by Jennifer Robinson on January 31, 2019

SOURCES:

Orphanet: "Acquired generalized lipodystrophy," "Partial acquired lipodystrophy."

Medscape: "Localized Lipodystrophy."

FDA: "FDA approves Myalept to treat rare metabolic disease."

Lipodystrophy United: "About Lipodystrophy."

NORD Physician Guides: "Acquired Lipodystrophies."

University of Texas Southwestern Medical Center: "Lipodystrophy," "Lipodystrophy Therapies," "Acquired: Generalized Lipodystrophy (AGL; Lawrence Syndrome)," "Acquired: Partial Lipodystrophy (Barraquer-Simons Syndrome)," "Acquired: Localized."

KidsHealth: "Acanthosis Nigricans."

AACE Lipodystrophy Detection Consensus Statement, , January-February 2013. Endocrine Practice

Endocrine Society, Resource Room Slide Series: "Lipodystrophy: Metabolic and Clinical Aspects."

DermNet NZ: "Lipodystrophy."

Kumar, R. , January 2000. Indian Pediatrics

Reviewed by Jennifer Robinson on January 31, 2019

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