There are no symptoms in the early stages of diabetic nephropathy. If you have kidney damage, you may have small amounts of protein leaking into your urine (albuminuria). Normally, protein is not found in urine except during periods of high fever, strenuous exercise, pregnancy, or infection.
Not everyone with diabetes will develop diabetic nephropathy. In people with type 1 diabetes, diabetic nephropathy is more likely to develop 5 to 10 years or more after the onset of diabetes. People with type 2 diabetes may find out that they already have a small amount of protein in the urine at the time diabetes is diagnosed, because they may have had diabetes for several years.
As diabetic nephropathy progresses, your kidneys cannot do their job as well. They cannot clear toxins or drugs from your body as well. And they cannot balance the chemicals in your blood very well. You may:
- Lose more protein in your urine.
- Have higher blood pressure.
- Have higher cholesterol and triglyceride levels.
You may have symptoms if your nephropathy gets worse. These symptoms include:
- Swelling (edema), first in the feet and legs and later throughout your body.
- Poor appetite.
- Weight loss.
- Feeling tired or worn out.
- Nausea or vomiting.
- Trouble sleeping.