Health Benefits of L-Tyrosine

L-tyrosine is one form of the amino acid tyrosine.  It is a non-essential amino acid, meaning that you don't have to get it from food. The body manufactures it, using another amino acid, phenylalanine. You may see tyrosine sold in supplement form with or without the "L."

Tyrosine is present in all tissues of the human body and in most of its fluids. It helps the body produce enzymes, thyroid hormones, and the skin pigment melanin. It also helps the body produce neurotransmitters that helps nerve cells communicate. Tyrosine is particularly important in the production of epinephrine, norepinephrine, and dopamine.

Most people do not need to take L-tyrosine because their bodies have a mechanism for regulating tyrosine supply. If you do not consume enough tyrosine from food, your body can make more. If you consume too much, your body will break it down and get rid of it. 

Health Benefits

Although most people do not need to take L-tyrosine, it may be beneficial in certain circumstances, including these:

Treatment of PKU

For a few people, tyrosine is an essential amino acid. These are people who have phenylketonuria (PKU). PKU is a serious condition in which phenylalanine builds up in the body. The main treatment for PKU is restricting dietary sources of phenylalanine. Treatment might also include the use of L-tyrosine as a supplement.  

Mental Alertness

Treatment with tyrosine may help humans perform in stressful situations, such as being exposed to extreme weather or being asked to perform certain cognitive tasks. In several studies, those taking tyrosine did not exhibit the processing problems or the memory deficits that would normally occur in difficult situations.

Coping With Sleep Deprivation

Tyrosine may also help you stay mentally sharp when you have lost sleep. In one study, subjects were kept awake for over 24 hours. Those who took tyrosine performed much better on two types of tasks than those who took a placebo. The effect lasted around three hours.

Anti-Depressant Action

Because tyrosine is turned into the brain chemicals dopamine and norepinephrine, it may play a role in relieving depression. An analysis of several studies found that tyrosine might be effective in treating mild-to-moderate depression.

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Health Risks

L-tyrosine is rated as likely or possibly safe at most dosages, but you should still talk to your doctor before taking it. It can interact with medicines, including some medications taken for depression and levodopa, taken for Parkinson's disease. Women who are pregnant or breast-feeding should not take L-tyrosine. Also, you should not take it if you have these conditions: 

Thyroid Disease

Since tyrosine is involved in the production of thyroid hormones, you should not use L-tyrosine if you have a thyroid condition such as hyperthyroidism or Graves disease. It could cause your levels to go too high.

Migraines

Some tyrosine is converted into the neurotransmitter epinephrine. During this process, a substance called tyramine is created. Tyramine can trigger a migraine headache by causing blood vessels to constrict and then dilate. For this reason, those who are susceptible to migraines should not take L-tyrosine. 

Amounts and Dosage

A typical dosage for L-tyrosine is 150 milligrams daily. You should take tyrosine supplements before meals, preferably divided into 3 daily doses. Your body might use tyrosine more effectively if you take it with vitamin B6, folate, and copper.

Tyrosine is abundant in many foods, especially traditional sources of protein like peanuts, fish, chicken, turkey, soy, and cottage cheese. It also occurs in pumpkin seeds, sesame seeds, avocado, and bananas. 

WebMD Medical Reference Reviewed by Dan Brennan, MD on November 07, 2020

Sources

SOURCES:

Alternative Medical Review: "Use of neurotransmitter precursors for treatment of depression."

The American Journal of Clinical Nutrition: "Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets."

Aviation, Space, and Environmental Medicine: "The effects of tyrosine on cognitive performance during extended wakefulness."

Kapalka, G. Nutritional and Herbal Therapies for Children and Adolescents, Academic Press, 2010.

Mount Sinai: "Tyrosine."

National Headache Foundation: "Tyramine."

NIH PubChem: "Tyrosine."

Pharmacology, Biochemistry, and Behavior: "Behavioral and cognitive effects of tyrosine intake in healthy human adults."

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