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How much SAM-e should you take?

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There is no established ideal dose of SAM-e. For depression, many studies have used between 400-1,600 milligrams daily. For osteoarthritis, 600-1,200 milligrams daily of SAM-e divided into three doses is common. Ask your doctor for advice. Sometimes, the dose of SAM-e is increased gradually over a few weeks. This can help reduce side effects such as restlessness or anxiety.

From: SAM-e (S-adenosylmethionine, SAMe) WebMD Medical Reference

SOURCES:

Fundukian, L., ed. , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Memorial Sloan-Kettering Cancer Center web site: “About Herbs: SAM-e.”

Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease."

Natural Medicines Comprehensive Database web site: “SAMe.”

Natural Standard Patient Monograph: “SAMe.”

Reviewed by Melinda Ratini on March 26, 2019

SOURCES:

Fundukian, L., ed. , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Memorial Sloan-Kettering Cancer Center web site: “About Herbs: SAM-e.”

Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease."

Natural Medicines Comprehensive Database web site: “SAMe.”

Natural Standard Patient Monograph: “SAMe.”

Reviewed by Melinda Ratini on March 26, 2019

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Can you get SAM-e naturally from foods?

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