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What are interactions of SAM-e?

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If you take any medicines regularly, talk to your doctor before you start using SAM-e supplements. SAM-e could be dangerous when combined with antidepressants or supplements that treat depression, like St. John's wort. SAM-e could also interact with some prescription painkillers, cough medicines, and treatments for diabetes and Parkinson's disease. People taking MAOIs should not use SAM-e without discussing it with their doctor.

From: SAM-e (S-adenosylmethionine, SAMe) WebMD Medical Reference

SOURCES:

Fundukian, L., ed. , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Memorial Sloan-Kettering Cancer Center web site: “About Herbs: SAM-e.”

Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease."

Natural Medicines Comprehensive Database web site: “SAMe.”

Natural Standard Patient Monograph: “SAMe.”

Reviewed by Melinda Ratini on March 26, 2019

SOURCES:

Fundukian, L., ed. , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Memorial Sloan-Kettering Cancer Center web site: “About Herbs: SAM-e.”

Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease."

Natural Medicines Comprehensive Database web site: “SAMe.”

Natural Standard Patient Monograph: “SAMe.”

Reviewed by Melinda Ratini on March 26, 2019

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Who shouldn't take SAM-e?

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THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

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