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What are symptoms of severe niacin deficiency?

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Severe niacin deficiency, called pellagra, can cause symptoms related to the skin, digestive system, and nervous system. They include:

  • Thick, scaly pigmented rash on skin exposed to sunlight
  • Swollen mouth and bright red tongue
  • Vomiting and diarrhea
  • Headache
  • Apathy
  • Fatigue
  • Depression
  • Memory loss

From: Niacin Deficiency WebMD Medical Reference

SOURCES: MedlinePlus: "Pellagra." University of Maryland Medical Center: "Vitamin B3 (Niacin)." University of Florida Institute of Food and Agricultural Sciences Extension: "Facts about Niacin."Oregon State University Linus Pauling Institute: "Niacin." MedlinePlus: "Niacin (vitamin B3, nicotinic acid), Niacinamide."



Merck Manual: "Niacin"

Reviewed by Christine Mikstas on May 29, 2019

SOURCES: MedlinePlus: "Pellagra." University of Maryland Medical Center: "Vitamin B3 (Niacin)." University of Florida Institute of Food and Agricultural Sciences Extension: "Facts about Niacin."Oregon State University Linus Pauling Institute: "Niacin." MedlinePlus: "Niacin (vitamin B3, nicotinic acid), Niacinamide."



Merck Manual: "Niacin"

Reviewed by Christine Mikstas on May 29, 2019

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