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Why do people take SAM-e?

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There's evidence that SAM-e can be a treatment for osteoarthritis pain. Some studies have found that oral SAM-e works as well as NSAID painkillers, such as ibuprofen. SAM-e takes longer to act than drugs, but it also has fewer side effects.

SAM-e has also been used to treat depression for many years. Some studies have found that SAM-e might work as well as tricyclic antidepressant, but many of these studies were flawed or too small to be conclusive.

From: SAM-e (S-adenosylmethionine, SAMe) WebMD Medical Reference

SOURCES:

Fundukian, L., ed. , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Memorial Sloan-Kettering Cancer Center web site: “About Herbs: SAM-e.”

Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease."

Natural Medicines Comprehensive Database web site: “SAMe.”

Natural Standard Patient Monograph: “SAMe.”

Reviewed by Melinda Ratini on March 26, 2019

SOURCES:

Fundukian, L., ed. , third edition, 2009. The Gale Encyclopedia of Alternative Medicine

Memorial Sloan-Kettering Cancer Center web site: “About Herbs: SAM-e.”

Agency for Healthcare Research and Quality web site: "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease."

Natural Medicines Comprehensive Database web site: “SAMe.”

Natural Standard Patient Monograph: “SAMe.”

Reviewed by Melinda Ratini on March 26, 2019

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