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What causes low gamma-GT intrahepatic cholestasis?

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The disease can be passed down in families that carry a specific gene -- a set of instructions that tell your body's cells how to reproduce. If your child has the disorder, a gene that helps form the liver carries faulty instructions.

When that happens, bile can't flow through your child's liver, leading to a condition called cholestasis. One of the signs is that his body doesn't make enough of a chemical called gamma-glutamyl transferase, or gamma-GT for short, that helps digestion.

SOURCES:

National Organization for Rare Disorders: "Low Gamma-GT Familial Intrahepatic Cholestasis."

National Institute of Diabetes and Digestive and Kidney Diseases: "The Digestive System & How it Works."

National Library of Medicine: "How does the liver work?"

National Library of Medicine, Genetics Home Reference: "Progressive familial intrahepatic cholestasis."

Children's Liver Disease Foundation: "Progressive Familial Intrahepatic Cholestasis."

Childhood Liver Disease Research Network: "What is Progressive Familial Intrahepatic Cholestasis (PFIC)?"

Cincinnati Children's Health Center: "Progressive Familial Intrahepatic Cholestasis."

California Pacific Medical Center: "MELD and the Waiting List for Liver Transplant."

Reviewed by Dan Brennan on February 12, 2018

SOURCES:

National Organization for Rare Disorders: "Low Gamma-GT Familial Intrahepatic Cholestasis."

National Institute of Diabetes and Digestive and Kidney Diseases: "The Digestive System & How it Works."

National Library of Medicine: "How does the liver work?"

National Library of Medicine, Genetics Home Reference: "Progressive familial intrahepatic cholestasis."

Children's Liver Disease Foundation: "Progressive Familial Intrahepatic Cholestasis."

Childhood Liver Disease Research Network: "What is Progressive Familial Intrahepatic Cholestasis (PFIC)?"

Cincinnati Children's Health Center: "Progressive Familial Intrahepatic Cholestasis."

California Pacific Medical Center: "MELD and the Waiting List for Liver Transplant."

Reviewed by Dan Brennan on February 12, 2018

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What is gastroparesis?

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