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What medication is suggested for chronic constipation?

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If your constipation is caused by irritable bowel syndrome or chronic idiopathic constipation, your doctor may prescribe you a chloride channel activator such as lubiprostone (Amitiza). It works by turning on switches in your cells that tell more fluid to come into your gastrointestinal tract. That can help:

  • Ease stomach pain
  • Soften your stool
  • Keep you from needing to strain when you go
  • Increase the number of times you need to go to the bathroom Guanylate cyclase-C agonists are also used for patients with chronic idiopathic constipation. These medications, which include linaclotide (Linzess) and plecanatide (Trulance), help make you more regular. They can lessen the pain in your abdomen and make bowel movements happen more often.

Sources:

Dartmouth-Hitchcock: “Constipation.”

Mayo Clinic: “Constipation.”

The National Institute of Diabetes and Digestive and Kidney Diseases. American Academy of Family Physicians: “Constipation.”

MedlinePlus: “Lubiprostone.”

FDA: “FDA approves Trulance for Chronic Idiopathic Constipation.”

UpToDate: “Constipation Overview,” “Lubiprostone: Drug information,” “Linaclotide: Drug information,” “Plecanatide: Drug information.”

Canadian Journal of Gastroenterology: “What is chronic constipation? Definition and diagnosis.”

American Family Physician: “Diagnostic Approach to Chronic Constipation in Adults.”

Reviewed by Jennifer Robinson on February 1, 2019

Sources:

Dartmouth-Hitchcock: “Constipation.”

Mayo Clinic: “Constipation.”

The National Institute of Diabetes and Digestive and Kidney Diseases. American Academy of Family Physicians: “Constipation.”

MedlinePlus: “Lubiprostone.”

FDA: “FDA approves Trulance for Chronic Idiopathic Constipation.”

UpToDate: “Constipation Overview,” “Lubiprostone: Drug information,” “Linaclotide: Drug information,” “Plecanatide: Drug information.”

Canadian Journal of Gastroenterology: “What is chronic constipation? Definition and diagnosis.”

American Family Physician: “Diagnostic Approach to Chronic Constipation in Adults.”

Reviewed by Jennifer Robinson on February 1, 2019

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What fiber supplements can be used to treat chronic constipation?

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