Peptic Ulcer Disease - Medications

Medicines are used to:

Medicine choices

Medicines to reduce stomach acid

Medicines that reduce the amount of acid produced by the stomach are used to treat all forms of peptic ulcer disease.

  • Antacids (such as Tums)
  • Acid reducers
    • H2 blockers (such as Zantac). Some H2 blockers are available without a prescription.
    • Proton pump inhibitors (PPIs) (such as Prilosec). Some PPIs are available without a prescription.

Medicines to kill H. pylori bacteria

Doctors prescribe combination drug therapy to cure infection with H. pylori bacteria. This usually includes at least two antibiotics, a proton pump inhibitor, and sometimes a bismuth compound.

Medicines to protect the stomach

Medicines used to protect the stomach from damage caused by frequent use of aspirin or other NSAIDs include:

  • Acid reducers. These include:
    • H2 blockers (such as Zantac).
    • Proton pump inhibitors (PPIs) (such as Prilosec).
  • Prostaglandin analogs (such as Cytotec).

You can get some H2 blockers and PPIs without a prescription (over the counter or OTC). If you are using OTC acid reducers (such as Prilosec or Pepcid) to help with your symptoms for more than 10 to 14 days at a time, or if your symptoms are very bad, be sure to see your doctor.

WebMD Medical Reference from Healthwise
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