Who should not take Piroxicam?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • anemia
  • an increased risk of bleeding
  • high blood pressure
  • chronic heart failure
  • a blood clot
  • visible water retention
  • pregnancy
  • tobacco smoking
  • time immediately after coronary bypass surgery
  • chronic kidney disease stage 4 (severe)
  • kidney disease with likely reduction in kidney function
  • aspirin exacerbated respiratory disease
  • systemic mastocytosis
  • increased risk of bleeding due to clotting disorder
  • alcoholism
  • a heart attack
  • a stroke
  • stomach or intestinal ulcer
  • bleeding of the stomach or intestines
  • weakened patient
  • a rupture in the wall of the stomach or intestine
  • increased cardiovascular event risk
  • CYP2C9 poor metabolizer
  • chronic kidney disease stage 5 (failure)
  • history of gastric bypass surgery


  • NSAIDS (Non-Steroidal Anti-Inflammatory Drug)
  • Salicylates

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.