Oral Fluoroquinolones/Sevelamer Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Sevelamer may bind to your fluoroquinolone antibiotic in your digestive tract and prevent your body from absorbing it.

What might happen:

The amount of fluoroquinolone antibiotic in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Time your medicines so that you take your fluoroquinolone antibiotic at least two hours before or six hours after your sevelamer. Let your healthcare professional know if your condition does not improve or worsens. Your doctor may need to change your antibiotic.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Kays MB, Overholser BR, Mueller BA, Moe SM, Sowinski KM. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis 2003 Dec;42(6):1253-9.
  • 2.Renagel (sevelamer hydrochloride) US prescribing information. Genzyme Corporation March 9, 2016.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.