This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines ca slow down how quickly your liver processes pioglitazone.
What might happen:
The amount of pioglitazone in your blood may increase and it may lower your blood sugar too much.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want you to check your blood sugar more frequently when you first start taking these medicines together and if you stop taking gemfibrozil. Inform your healthcare professionals if you have any signs of low blood sugar such as sweating, rapid heartbeat, and dizziness. Your doctor may need to change the dose of your diabetes medicine or change your cholesterol medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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2.Actos (pioglitazone hydrochloride) US prescribing information. Takeda Pharmaceuticals Inc. November, 2013.
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6.Niemi M, Backman JT, Granfors M, Laitila J, Neuvonen M, Neuvonen PJ. Gemfibrozil considerably increases the plasma concentrations of rosiglitazone. Diabetologia 2003 Oct;46(10):1319-23.
7.Avandia (rosiglitazone) US prescribing information. GlaxoSmithKline May, 2012.
8.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
9.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..