Colchicine/Fibrates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines can cause muscle damage.

What might happen:

Using these medicine together may damage your muscles.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Make sure your doctor knows if you have any kidney problems, which may make the interaction worse. Your doctor may need to change your medicine or the dose of your colchicine.Let your doctor know right away if you have any unexpected muscle pain, tenderness or weakness; unexplained tiredness; discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Colcrys (colchicine) US prescribing information. AR Scientific, Inc. July, 2011.
  • 2.Lopid (gemfibrozil) US prescribing information. Pfizer Pharmaceuticals, Ltd. April 18. 2017.
  • 3.Atmaca H, Sayarlioglu H, Kulah E, Demircan N, Akpolat T. Rhabdomyolysis associated with gemfibrozil-colchicine therapy. Ann Pharmacother 2002 Nov; 36(11):1719-21.
  • 4.Sugie M, Kuriki A, Arai D, Ichikawa H, Kawamura M. A case report of acute neuromyopathy induced by concomitant use of colchicine and bezafibrate. No To Shinkei 2005 Sep;57(9):785-90.