Warfarin/Leflunomide Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

How this interaction occurs is not known.

What might happen:

You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You may need to have your bleeding times checked more often, especially when you first start taking leflunomide or if you stop taking leflunomide. If you have any signs of bleeding, such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Chonlahan J, Halloran MA, Hammonds A. Leflunomide and warfarin interaction: case report and review of the literature. Pharmacotherapy 2006 Jun;26(6):868-71.
  • 2.Lim V, Pande I. Leflunomide can potentiate the anticoagulant effect of warfarin. BMJ 2002 Dec 7;325(7376):1333.
  • 3.Lim V, Pande I. Erratum: Leflunomide can potentiate the anticoagulant effect of warfarin. BMJ 2003 Feb 22;326(7386):432.