Selected Cation-Donating Antacids/Sodium Polystyrene Sulfonate Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, they may bind together in your intestine.
What might happen:
Sodium polystyrene sulfonate may not work as well at lowering your potassium level. You may also experience a disturbance in the acid balance in your blood.
What you should do about this interaction:
If you experience breathing difficulty, chest pain, slow or irregular heartbeat, confusion, muscle weakness, or numbness and tingling of the hands and feet, contact your doctor. It may be necessary to adjust the times of day that you take one or both medicines. Your doctor may stop your antacid or change you to a different medicine. This interaction may be worse if you have kidney disease.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Kayexalate (sodium polystyrene sulfonate) US prescribing information. Concordia Pharmaceuticals Inc. July 31, 2017.
- 2.Schroeder ET. Alkalosis resulting from combined administration of a "nonsystemic" antacid and a cation-exchange resin. Gastroenterology 1969 May;56(5):868-74.
- 3.Nassif F, Sinnassamy P, Bensman A. A cause of alkalosis in children under hemodialysis: combined administration of magnesium hydroxide and polystyrene sodium sulfonate. Presse Med 1987 May 30;16(20):1003.
- 4.Madias NE, Levey AS. Metabolic alkalosis due to absorption of "nonabsorbable" antacids. Am J Med 1983 Jan;74(1):155-8.
- 5.Ziessman HA. Alkalosis and seizure due to a cation-exchange resin and magnesium hydroxide. South Med J 1976 Apr;69(4):497-9.
- 6.Fernandez PC, Kovnat PJ. Metabolic acidosis reversed by the combination of magnesium hydroxide and a cation-exchange resin. N Engl J Med 1972 Jan 6; 286(1):23-4.
- 7.Baluarte HJ, Prebis J, Goldberg M, Gruskin AB. Metabolic alkalosis in an anephric child caused by the combined use of Kayexalate and Basaljel. J Pediatr 1978 Feb;92(2):237-9.
- 8.Foresti V. Intestinal obstruction due to kayexalate in a patient concurrently treated with aluminum hydroxide and morphine sulfate. Clin Nephrol 1994 Apr;41(4):252.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.