Neuromuscular Blocking Agents/Quinine Derivatives Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the effects of the neuromuscular blocking medicine may increase and cause toxic effects.

What might happen:

You may experience an increase in the effects of the neuromuscular blocker.

What you should do about this interaction:

Neuromuscular blockers are only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Grogono AW. Anaesthesia for a atrial defibrillation. Effect of quinidine on muscular relaxation. Lancet 1963 Nov 16;2:1039-40.
  • 2.Schmidt JL, Vick NA, Sadove MS. The effect of quinidine on the action of muscle relaxants. JAMA 1963 Feb 23;183(8):669-71.
  • 3.Cuthbert MF. The effect of quinidine and procainamide on the neuromuscular blocking action of suxamethonium. Br J Anaesth 1966 Oct;38(10):775-9.
  • 4.Kambam JR, Franks JJ, Naukam R, Sastry BV. Effect of quinidine on plasma cholinesterase activity and succinylcholine neuromuscular blockade. Anesthesiology 1987 Nov;67(5):858-60.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.