Metoclopramide/Quinidine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Quinidine may slow down how quickly your liver processes metoclopramide.

What might happen:

The amount of metoclopramide in your blood may increase. This can increase the risk of abnormal, uncontrollable muscle movements called tardive dyskinesia. There is no cure for tardive dyskinesia, but symptoms may lessen or go away after you stop taking the medicines; however, the symptoms may be permanent.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Contact your doctor right away if you develop any movements you cannot stop or control such as: lip smacking, chewing, puckering of the mouth, frowning or scowling, sticking out the tongue, blinking and moving the eyes, and shaking of the arms and/or legs.

  • 1.Reglan (metoclopramide) tablets US prescribing information. ANI Pharmaceuticals, Inc. August 29, 2017.
  • 2.Vlase L, Leucuta A, Farcau D, Nanulescu M. Pharmacokinetic interaction between fluoxetine and metoclopramide in healthy volunteers. Biopharm Drug Dispos 2006 Sep;27(6):285-9.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.