Selected CYP2C9 Substrates/Nitisinone Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nitisinone may slow down how quickly your liver processes fluvastatin, fosphenytoin, glimepiride, glipizide, phenytoin, tolbutamide, and warfarin.
What might happen:
Your risk for side effects from fluvastatin, fosphenytoin, glimepiride, glipizide, phenytoin, tolbutamide, and warfarin may increase.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. They may want to more closely monitor you for side effects, order blood tests, or adjust the dose of your medications.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Orfadin (nitisinone) US prescribing information. Rare Diseases Therapeutics, Inc. May, 2019.
- 2.Huledal G, Olsson B, Onnestam K, Dalen P, Lindqvist D, Kruse M, Broijersen A. Non randomized study on the potential of nitisinone to inhibit cytochrome P450 2C9, 2D6, 2E1 and the organic anion transporters OAT1 and OAT3 in healthy volunteers. Eur J Clin Pharmacol 2019 Mar;75(3):313-320.
- 3.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2019..
- 4.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.