Itraconazole; Ketoconazole/Selected 3A4 Inhibitors Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may slow down how quickly your liver processes itraconazole and ketoconazole. Itraconazole and ketoconazole may slow down how quickly your liver processes ritonavir and may speed up how quickly your liver processes lopinavir.
What might happen:
The amount of itraconazole and ketoconazole in your blood may increase and cause side effects. You may notice more side effects from your ritonavir as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to decrease the dose of itraconazole and ketoconazole. Let your doctor know if you have nausea, yellowing of the eyes or skin, unusual weakness, dark urine, pale stools, numbness or tingling of the hands or feet, depression, trouble breathing, or swelling of the ankles or feet.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir) prescribing information. Gilead Sciences, Inc. February 6, 2019.
- 2.Prezista (darunavir) US prescribing information. Tibotec Inc. January, 2019.
- 3.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline March, 2019.
- 4.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories November, 2018.
- 5.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. June, 2018.
- 6.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2018.
- 7.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. March, 2019.
- 8.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.