Who should not take Bupropion HCl SR?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • spread of cancer to the brain
  • tumor of the brain or spinal cord
  • symptoms from alcohol withdrawal
  • manic-depression
  • psychotic disorder
  • suicidal thoughts
  • alcohol use disorder
  • dependence on opioid-type drugs
  • anorexia nervosa
  • bulimia
  • a low seizure threshold
  • closed angle glaucoma
  • high blood pressure
  • a heart attack
  • severe liver disease
  • decreased kidney function
  • seizures
  • weight loss
  • seizure caused by sudden withdrawal of benzodiazepine
  • stimulant drug dependence
  • sedative drug dependence
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • Child-Pugh class A liver impairment
  • Child-Pugh class B liver impairment
  • Child-Pugh class C liver impairment

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.