Adenosine; Regadenoson/Dipyridamole Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process adenosine more slowly.

What might happen:

Your blood levels of adenosine may increase. This may cause your heartbeat to increase.

What you should do about this interaction:

Adenosine is usually used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery or tests, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticalsYour healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Biaggioni I, Onrot J, Hollister AS, Robertson D. Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole. Life Sci 1986 Dec 8;39(23):2229-36.
  • 2.Watt AH, Bernard MS, Webster J, Passani SL, Stephens MR, Routledge PA. Intravenous adenosine in the treatment of supraventricular tachycardia: a dose-ranging study and interaction with dipyridamole. Br J Clin Pharmacol 1986 Feb;21(2):227-30.
  • 3.Conradson TB, Dixon CM, Clarke B, Barnes PJ. Cardiovascular effects of infused adenosine in man: potentiation by dipyridamole. Acta Physiol Scand 1987 Mar;129(3):387-91.
  • 4.German DC, Kredich NM, Bjornsson TD. Oral dipyridamole increases plasma adenosine levels in human beings. Clin Pharmacol Ther 1989 Jan;45(1):80-4.
  • 5.Lexiscan (regadenoson) US prescribing information. Astellas Pharma US, Inc. May, 2018.
  • 6.Adenoscan (adenosine) US prescribing information. Astellas Pharma US, Inc. August, 2014.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.