Who should not take Mirtazapine?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • high cholesterol
  • high amount of triglyceride in the blood
  • low amount of sodium in the blood
  • dehydration
  • overweight
  • manic behavior
  • a form of mania that has a lower severity of symptoms
  • manic-depression
  • suicidal thoughts
  • neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion
  • closed angle glaucoma
  • a heart attack
  • angina, a type of chest pain
  • torsades de pointes, a type of abnormal heart rhythm
  • prolonged QT interval on EKG
  • abnormal EKG with QT changes from birth
  • a stroke
  • a disorder of the blood vessels of the brain
  • orthostatic hypotension, a form of low blood pressure
  • low blood pressure
  • liver problems
  • seizures
  • a feeling of restlessness with inability to sit still
  • weight gain
  • abnormal liver function tests
  • decreased blood volume
  • moderate to severe kidney impairment
  • a significant drop in a certain type of white blood cell called a neutrophil
  • muscle pain or tenderness with increase creatine kinase
  • acute thromboembolic stroke
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.