Succinylcholine/Metoclopramide Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process succinylcholine properly.

What might happen:

The effects of succinylcholine on your breathing may increase or last longer.

What you should do about this interaction:

Succinylcholine is used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all healthcare professionals are aware of all the different medicines that you are taking. This includes prescription and non-prescription medicine, herbal drugs, and nutraceuticals.If these two medicines are given together you should have your breathing monitored very closely while taking them.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Turner DR, Kao YJ, Bivona C. Neuromuscular block by suxamethonium following treatment with histamine type 2 antagonists or metoclopramide. Br J Anaesth 1989 Sep;63(3):348-50.
  • 2.Kao YJ, Turner DR. Prolongation of succinylcholine block by metoclopramide. Anesthesiology 1989 Jun;70(6):905-8.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.