SPRYCEL Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • low amount of phosphate in the blood
  • low amount of calcium in the blood
  • anemia
  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • bleeding
  • escape of fluid into the lungs
  • bleeding of the stomach or intestines
  • trouble breathing

If experienced, these tend to have a Less Severe expression i

  • constipation
  • itching
  • joint pain
  • dizziness
  • low energy
  • pain
  • chills
  • a skin rash
  • decreased appetite
  • weight gain
  • weight loss
  • cough
  • nausea
  • vomiting
  • diarrhea
  • stomach cramps
  • abdominal bloating
  • generalized weakness
  • a feeling of general discomfort called malaise
  • pain in the muscles or bones

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • shingles
  • a herpes simplex infection
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • confusion
  • high blood pressure
  • a heart attack
  • fluid in the covering of the heart or pericardium
  • prolonged QT interval on EKG
  • abnormal heart rhythm
  • heart failure
  • an enlarged heart
  • low blood pressure
  • pneumonia
  • asthma
  • fluid in the lungs
  • a type of inflammation of the lung called interstitial pneumonitis
  • inflammation of the large intestine
  • inflammation of the small and large intestine
  • heart throbbing or pounding
  • increased creatine kinase levels
  • tumor lysis syndrome

If experienced, these tend to have a Less Severe expression i

  • mood changes
  • dry eye
  • ringing in the ears
  • a type of stomach irritation called gastritis
  • indigestion
  • enlarged breasts
  • skin inflammation
  • increased sensitivity of the skin to the sun
  • hair loss
  • acne
  • dry skin
  • muscle weakness
  • muscle stiffness
  • muscle pain
  • drowsiness
  • difficulty sleeping
  • excessive sweating
  • muscle tremors
  • taste impairment
  • temporary redness of face and neck
  • difficulty swallowing
  • an increased need to urinate often
  • bruising

RARE side effects

If experienced, these tend to have a Severe expression i

  • a sudden worsening of angina called acute coronary syndrome
  • angina, a type of chest pain
  • a low supply of oxygen rich blood to the heart
  • a clot in the lung
  • pulmonary hypertension
  • rapid ventricular heartbeat
  • atrial fibrillation
  • atrial flutter
  • a hemorrhage in the brain
  • a transient ischemic attack, a type of stroke that lasts only a few minutes
  • obstruction of a blood vessel by a blood clot
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • acute respiratory distress syndrome, a type of lung disorder
  • inflammation of the esophagus
  • acute liver failure
  • inflammation of the liver called hepatitis
  • blockage of normal bile flow
  • nephrotic syndrome, a type of kidney disorder
  • kidney failure
  • inflammation of the skin with blisters
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • seizures
  • erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
  • ascites
  • abnormal liver function tests
  • reactivation of hepatitis B infection
  • pancreatitis
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • pulmonary arterial hypertension
  • pure red cell aplasia

If experienced, these tend to have a Less Severe expression i

  • a nail disorder
  • headache
  • a change in voice

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.