If you are:
Only When Necessary: REPORTS OF ARTHROPATHY WITH QUINOLONES IN ANIMAL STUDIES; CONSIDER RISK/BENEFIT
Precaution: LIMITED DATA SUGGEST LOW AMOUNTS EXCRETED,W/NO KNOWN ADVERSE EFFECT IN INFANT
An adult over 60:
management or monitoring precaution: Musculoskeletal-Risk for tendinitis and tendon rupture increases with concomitant corticosteroid use. Cardiovascular-Elderly may be more susceptible to QT-prolongation. Monitor and correct electrolytes (e.g., K, Mg). Neuro/Psych-Risk for peripheral neuropathy which may affect walking and increase fall risk.
Giving Levaquin to a child under 12:
management or monitoring precaution: Increased risk of musculoskeletal disorder, tendinopathy. Risk-benefit appropriate only for inhalational anthrax and plague. Safety not established for treatment duration >14 days.
Contraindication: No safety data age < 6 months. Increased risk of musculoskeletal disorders. Joint lesions observed in animal studies.