Topiramate/Carbonic Anhydrase Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

In addition to treating seizures, topiramate also inhibits the carbonic anhydrase enzyme. When this enzyme is inhibited, your kidneys do not remove as much citrate as they normally do and the acidity of your urine is decreased. These conditions can increase the risk of a kidney stone forming.

What might happen:

If you use these medicines together, you may get a kidney stone.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Also tell your doctor if you are a special diet for weight loss or epilepsy. Some of these diets may also increase your risk of a kidney stone. Your doctor may want to change one of your medicines. You may need to drink more water while taking these medicines together. If you develop any symptoms of a kidney stone (blood in your urine, a burning sensation when urinating, or pain in the lower back), contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Topamax (topiramate) US prescribing information. Janssen Pharmaceuticals, Inc. May, 2019..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.