If you are:
FDB Only When Necessary: INSUFF HUMAN DATA; POORLY CONTROLLED DIABETES MAY INCREASE MATERNAL/FETAL RISK
Only When Necessary: RISK OF HYPOGLYCEMIA IN NEONATE IF USED NEAR DELIVERY
Precaution: INSUFFICIENT DATA AVAILABLE; ALTERNATIVE AGENTS MAY BE PREFERRED
Absolute Contraindication: NOT RECOMMEND;EXCRETED IN RATS; POSSIBILITY OF HYPOGLYCEMIA IN NURSING INFANT
An adult over 60:
management or monitoring precaution: Renal-Decreased renal function increases risk of hypoglycemia. Initiate at low dose, titrate slowly.
management or monitoring precaution: Cardiovascular-Box warning states the drug may cause or exacerbate CHF. Contraindicated in patients with NYHA Class III or IV heart failure. Monitor for weight gain, peripheral edema and new onset dyspnea. Hepatic-Monitor for elevations of serum transaminases. Musculoskeletal-Consider increased fracture risk.
Giving pioglitazone-glimepiride to a child under 12:
Severe Precaution: Not recommended in pediatrics. Risk of hypoglycemia and weight gain.
Severe Precaution: Possible risks include fracture, fluid retention and heart failure, bladder tumor. Not recommended.