If you are:
Not Recommended: DEVELOPMENTAL TOX IN ANIMALS; BINDS TO MATERNAL BONE & IS RELEASED OVER WKS-YRS
Only When Necessary:
Absolute Contraindication: SHOULD NOT BE ADMINISTERED IN LACTATION, BINDS TO BONE LONG-TERM
Precaution: Effect Unknown
An adult over 60:
management or monitoring precaution: General-Risk for fluid and electrolyte imbalances. Cardiovascular-Caution in patients with CHF, especially with renal impairment.
management or monitoring precaution: Renal-Nephrotoxicity risk is higher in the elderly; monitor renal function prior to giving dose. Avoid in severe impairment (CrCL<30 mL/min) and correct dehydration before administering dose.
Giving zoledronic acid 5 mg/100 mL in mannitol and water intravenous piggybck to a child under 12:
Severe Precaution: Increased risk of fever, arthralgia, hypocalcemia. Weigh risk-benefit. Not indicated per manufacturer.