Who should not take Margesic?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • caloric undernutrition
  • acute liver failure
  • liver problems
  • severe renal impairment
  • Shock
  • Overdose of the Drug Acetaminophen
  • Acute Inflammation of the Liver due to Hepatitis C Virus
  • high blood pressure
  • heart attack within the last 30 days
  • abnormal heart rhythm
  • Ulcer from Stomach Acid
  • Inflamed Colon and Small Intestine with Some Tissue Death
  • severe liver disease
  • seizures
  • Chronic Trouble Sleeping
  • moderate to severe kidney impairment
  • high amount of ammonium in the blood
  • Porphyria
  • Anemia
  • Decreased Blood Platelets
  • Decreased Neutrophils a Type of White Blood Cell
  • Having Thoughts of Suicide
  • alcoholism
  • drug abuse
  • depression
  • Hyperactive Behavior
  • Asthma Attack
  • Lung Failure causing Loss of Breath
  • Unconsciousness Resulting from Liver Cell Deterioration
  • kidney disease with reduction in kidney function
  • Temporarily Stops Breathing While Sleeping
  • Impaired Brain Function due to Liver Disease
  • Chronic Obstructive Lung Disease
  • Perform Complex Natural behaviors while Asleep


  • Xanthines
  • Coffee
  • Guarana
  • Barbiturates
  • Acetaminophen

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.