The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • systemic mastocytosis
  • anemia
  • increased risk of bleeding due to clotting disorder
  • an increased risk of bleeding
  • alcoholism
  • high blood pressure
  • a heart attack
  • chronic heart failure
  • abnormal bleeding in the brain resulting in damage to brain tissue, called a hemorrhagic stroke
  • a blood clot
  • stomach or intestinal ulcer
  • liver problems
  • bleeding of the stomach or intestines
  • kidney transplant
  • visible water retention
  • abnormal liver function tests
  • pregnancy
  • problems with food passing through the esophagus
  • a rupture in the wall of the stomach or intestine
  • tobacco smoking
  • increased cardiovascular event risk
  • time immediately after coronary bypass surgery
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function
  • aspirin exacerbated respiratory disease
  • history of gastric bypass surgery
  • history of kidney donation
  • serotonin syndrome, a type of disorder with high serotonin levels
  • migraine headache with temporary paralysis of one side
  • significant uncontrolled high blood pressure
  • a heart attack
  • Prinzmetal angina, a type of angina where chest pain occurs when at rest
  • angina, a type of chest pain
  • coronary artery disease
  • a low supply of oxygen rich blood to the heart
  • a stroke
  • cerebral ischemia, a lack of blood supply to the brain
  • peripheral vascular disease
  • an ischemic bowel, a condition where the blood flow to the intestine is significantly decreased
  • seizures
  • an abnormally fast heartbeat

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.