Selected Calcium Channel Blockers/Selected Azole Antifungals Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your antifungal may decrease the ability of your liver to remove the calcium channel blocker from your body.
What might happen:
The level of calcium channel blocker in your body may cause your blood pressure to decrease too much. Symptoms of low blood pressure include: irregular heartbeat, lightheadedness, nausea, drowsiness, confusion, and slurred speech. You may also notice swelling in your legs and/or feet.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to decrease the dose of your calcium channel blocker. Let your doctor know right away if you develop any signs of low blood pressure, a decreased heart rate, or swelling of the legs.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. May, 2018.
- 2.Sporanox (itraconazole) UK summary of product characteristics. Janssen-Cilag Ltd November, 2008.
- 3.Sporanox (itraconazole) Canadian prescribing information. Janssen-Ortho May 20, 2008.
- 4.Diflucan (fluconazole) US prescribing information. Pfizer Inc. March, 2020.
- 5.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
- 6.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc September, 2016.
- 7.Vfend (voriconazole) US prescribing information. Pfizer Inc. September, 2020.
- 8.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and- drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
- 9.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2019..
- 10.Jalava KM, Olkkola KT, Neuvonen PJ. Itraconazole greatly increases plasma concentrations and effects of felodipine. Clin Pharmacol Ther 1997 Apr; 61(4):410-5.
- 11.Plendil (felodipine) US prescribing information. AstraZeneca Pharmaceuticals LP November, 2003.
- 12.Neuvonen PJ, Suhonen R. Itraconazole interacts with felodipine. J Am Acad Dermatol 1995 Jul;33(1):134-5.
- 13.Kremens B, Brendel E, Bald M, Czyborra P, Michel MC. Loss of blood pressure control on withdrawal of fluconazole during nifedipine therapy. Br J Clin Pharmacol 1999 Jun;47(6):707-8.
- 14.Tailor SA, Gupta AK, Walker SE, Shear NH. Peripheral edema due to nifedipine-itraconazole interaction: a case report. Arch Dermatol 1996 Mar;132(3):350-2.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.