Levodopa/Tetrabenazine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Tetrabenazine prevents levodopa from working.

What might happen:

The effects of your levodopa may decrease and cause an increase in your symptoms of Parkinsonism.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if your Parkinson's symptoms become worse.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Tetrabenazine Australian prescribing information. iNova Pharmaceuticals (Aust) Pty Ltd April 12, 2017.
  • 2.Nitoman (tetrabenazine) Canadian prescribing information. Valeant Canada LP September 4, 2014.
  • 3.Tardiben (tetrabenazine) UK summary of product characteristics. AOP Orphan Pharmaceuticals AG April 4, 2017.
  • 4.Brusa L, Orlacchio A, Stefani A, Galati S, Pierantozzi M, Iani C, Mercuri NB. Tetrabenazine improves levodopa-induced peak-dose dyskinesias in patients with Parkinson's disease. Funct Neurol 2013 Apr-May;28(2):101-5.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.