SIMPONI Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • an infection
  • low levels of a type of white blood cell called neutrophils
  • high blood pressure
  • cellulitis
  • a high alanine transaminase level
  • a high aspartate transaminase level

If experienced, these tend to have a Less Severe expression i

  • an infection due to a virus
  • throat irritation
  • bronchitis
  • a skin rash

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • shingles
  • an infection due to a fungus
  • chronic heart failure
  • pneumonia
  • the flu
  • reactivation of a past tuberculosis infection
  • malignant lymphoma

If experienced, these tend to have a Less Severe expression i

  • dizziness
  • a feeling of pins and needles on skin

RARE side effects

If experienced, these tend to have a Severe expression i

  • an infection by the bacteria Listeria monocytogenes
  • an infection due to unusual mycobacteria
  • an infection due to the fungus Candida
  • a type of systemic fungal infection called coccidioidomycosis
  • a type of fungal lung infection called histoplasmosis
  • an infection by the fungus Blastomyces dermatitidis
  • a type of systemic fungal infection called aspergillosis
  • sarcoidosis
  • malignant melanoma, a type of skin cancer
  • cancer or malignancy
  • leukemia
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • low blood counts due to bone marrow failure
  • decreased blood platelets
  • very low levels of granulocytes, a type of white blood cell
  • low levels of white blood cells
  • multiple sclerosis
  • demyelination, a type of nervous system disorder
  • Guillain-Barre syndrome
  • sudden blindness and pain upon moving the eye
  • inflammation of the blood vessels
  • inflammation of blood vessels in the skin
  • a type of lung infection called Legionnaires' disease
  • pyelonephritis, infection and inflammation of the kidney and renal pelvis
  • inflammation of the skin with blisters
  • skin rash with sloughing
  • a condition with symptoms that resemble lupus
  • a significant drop in blood pressure due to bacterial infection
  • trouble breathing
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • lung tissue problem
  • reactivation of hepatitis B infection
  • drug therapy that worsens or flares psoriasis
  • hepatosplenic T-cell lymphoma
  • worsening of chronic heart failure
  • peripheral demyelinating neuropathy, a type of nerve disorder
  • a type of skin cancer called Merkel cell carcinoma

If experienced, these tend to have a Less Severe expression i

  • constipation
  • psoriasis
  • itching
  • hives
  • inflammation of the sac surrounding the joint - bursitis

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.