Bictegravir/Selected Strong CYP3A4 Inducers; Rifabutin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Carbamazepine, fosphenytoin, mitotane, phenobarbital, phenytoin, primidone, rifabutin, rifapentine, or St. John's wort may speed up how quickly your body processes bictegravir.

What might happen:

The amount of bictegravir in your blood may become less and may not work as well.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have taken carbamazepine, fosphenytoin, mitotane, phenobarbital, phenytoin, primidone, rifabutin, rifapentine, or St. John's wort in the last two weeks, or if you stop taking any of these medicines. Your doctor may want to adjust your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Biktarvy (bictegravir, emtricitabine, tenofovir alafenamide) US prescribing information. Gilead Sciences, Inc. June, 2019.
  • 2.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Department of Health and Human Services. Available at July 10, 2019.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.