Who should not take VOTRIENT?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • a bad infection
  • a condition with low thyroid hormone levels
  • low amount of magnesium in the blood
  • low amount of calcium in the blood
  • low amount of potassium in the blood
  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • significant uncontrolled high blood pressure
  • a heart attack
  • angina, a type of chest pain
  • torsades de pointes, a type of abnormal heart rhythm
  • prolonged QT interval on EKG
  • left ventricular heart failure
  • abnormal EKG with QT changes from birth
  • a hemorrhage in the brain
  • a localized weakening and ballooning in an artery wall called an arterial aneurysm
  • obstruction of a blood vessel by a blood clot
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • bleeding
  • a gastrointestinal tract fistula
  • damage to the liver and inflammation
  • liver problems
  • bleeding of the stomach or intestines
  • recent operation
  • high amount of bilirubin in the blood
  • diarrhea
  • elevation of proteins in the urine
  • abnormal liver function tests
  • impaired wound healing
  • pregnancy
  • a patient who is producing milk and breastfeeding
  • a rupture in the wall of the stomach or intestine
  • lung tissue problem
  • pancreatitis
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • acute thromboembolic stroke
  • reduced UGT1A1 enzyme activity due to *28 polymorphism
  • dissection of artery

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.