PROLIA Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • trouble breathing

If experienced, these tend to have a Less Severe expression i

  • low amount of phosphate in the blood
  • backache
  • low energy
  • nausea
  • generalized weakness

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • low amount of magnesium in the blood
  • low amount of potassium in the blood
  • high blood pressure

If experienced, these tend to have a Less Severe expression i

  • high cholesterol
  • anemia
  • throat irritation
  • a common cold
  • bronchitis
  • gastroesophageal reflux disease
  • indigestion
  • constipation
  • inflammation of the bladder
  • urinary tract infection
  • skin inflammation
  • a type of skin condition with redness and itching called eczema
  • inflammation of the skin due to an allergy
  • itching
  • joint pain
  • pain in the arms or legs
  • bone pain
  • sensation of spinning or whirling
  • dizziness
  • a skin rash
  • fluid retention in the legs, feet, arms or hands
  • decreased appetite
  • headache
  • cough
  • vomiting
  • gas
  • diarrhea
  • an infection of the ear
  • upper abdominal pain
  • back pain caused by a problem with the sciatic nerve

RARE side effects

If experienced, these tend to have a Severe expression i

  • erysipelas, a bacterial skin infection
  • an infection
  • a bad infection
  • cancer or malignancy
  • increased activity of the parathyroid gland
  • low amount of calcium in the blood
  • clouding of the lens of the eye called cataracts
  • angina, a type of chest pain
  • endocarditis, an infection of a heart valve
  • low blood pressure
  • a feeling of throat tightness
  • a significant type of allergic reaction called anaphylaxis
  • a hypersensitivity reaction to a drug
  • portions of the jaw bone to die from lack of blood circulation
  • pancreatitis
  • cellulitis
  • a cholesteatoma, an abnormal, noncancerous skin growth that develops in the middle part of the ear
  • an unusual and spontaneous bone break in the upper leg
  • a tooth abscess
  • bone necrosis of external ear canal

If experienced, these tend to have a Less Severe expression i

  • shingles
  • an earwax blockage
  • ringing in the ears
  • an earache
  • itching of the ear
  • hearing loss
  • erythema or skin redness
  • hair loss
  • difficulty sleeping
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.