Theophylline/Marijuana Smoke Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Smoking marijuana causes your body to process theophylline more quickly. Smoking tobacco and marijuana speeds up this process even more.
What might happen:
The blood level of your theophylline may decrease, so it may not work as well.
What you should do about this interaction:
Let your healthcare professionals know you are using marijuana, how much, and how frequently, or if you stop using marijuana. Your doctor may want to check your theophylline level if you start or stop marijuana use to be sure you are receiving the right dose.If you experience problems with your breathing, severe nausea/vomiting, tremors, heart palpitations or other effects, contact your doctor. It may be necessary to adjust the dose of your medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Levy RH Thummel KE Trager WF. Metabolic Drug Interactions (textbook). Metabolic Drug Interactions 2000.
- 2.Stout SM, Cimino NM. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev 2014 Feb;46(1):86-95.
- 3.Jusko WJ, Schentag JJ, Clark JH, Gardner M, Yurchak AM. Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Clin Pharmacol Ther 1978 Oct;24(4):405-10.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.