Selected CYP1A2 Substrates/Obeticholic acid Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Obeticholic acid can slow the breakdown of some medications such as tizanidine, pirfenidone, theophylline or tacrine.

What might happen:

The blood level of your affected medicine may rise, leading to an increase in side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your doctor may want to more closely monitor you for adverse effects or adjust the dose of your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.FDA (US Food and Drug Administration). Gastrointestinal Drug Advisory Committee (GIDAC) Meeting, FDA Background Document for NDA 207999 obeticholic acid. accessed at: /drugs/gastrointestinaldrugsadvisorycommittee/ucm494108.pdf March 15, 2016.
  • 2.Ocaliva (obeticholic acid) US prescribing information. Intercept Pharmaceuticals Inc. January, 2018.
  • 3.Esbriet (pirfenidone) US prescribing information. InterMune, Inc. October, 2014.
  • 4.Zanaflex (tizanidine hydrochloride) US prescribing information. Acordia Therapeutics, Inc. November 7, 2013.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.