YERVOY Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • a decreased number of lymphocytes in the blood
  • inflammation of the large intestine

If experienced, these tend to have a Less Severe expression i

  • itching
  • low energy
  • a skin rash
  • decreased appetite
  • weight loss
  • headache
  • nausea

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • overactive thyroid gland
  • a condition with low thyroid hormone levels
  • pituitary hormone deficiency
  • a hormone disorder where the body produces high levels of cortisol called Cushing's syndrome
  • anemia
  • inflammation of the small and large intestine
  • blocked bowels with decreased peristaltic movement
  • inflammation of the liver called hepatitis
  • abnormal liver function tests

If experienced, these tend to have a Less Severe expression i

  • skin inflammation
  • difficulty sleeping
  • vomiting

RARE side effects

If experienced, these tend to have a Severe expression i

  • sarcoidosis
  • decreased function of the adrenal gland
  • destruction of red blood cells by body's own antibodies
  • low blood counts due to bone marrow failure
  • an infection of the central nervous system called meningitis
  • encephalitis
  • a disorder of the peripheral nerves that enable movement called peripheral motor neuropathy
  • Guillain-Barre syndrome
  • myasthenia gravis, a skeletal muscle disorder
  • detachment of the retina of the eye
  • inflammation of the iris - the colored part of the eyeball
  • inflammation of the uvea of the eye
  • hearing loss
  • inflammation of the covering of the heart or pericardium
  • inflammation of the middle tissue heart muscle
  • allergic reaction causing inflammation of blood vessels
  • inflammation of the artery in the temple area
  • inflammation of the blood vessels
  • inflammation in the lungs due to an allergic reaction
  • a type of inflammation of the lung called interstitial pneumonitis
  • acute respiratory distress syndrome, a type of lung disorder
  • inflammation of the esophagus
  • stomach or intestinal ulcer
  • a hole in the intestine
  • liver inflammation resulting from an abnormal immune response
  • liver failure
  • a type of kidney inflammation called interstitial nephritis
  • kidney inflammation
  • kidney failure
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • muscle pain and stiffness in the shoulder, neck and pelvis
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • muscle weakness
  • muscle inflammation
  • a hypersensitivity reaction to a drug
  • rejection of a transplanted organ
  • graft-versus-host disease
  • inflammation of the duodenum
  • Hashimoto thyroiditis, a disease of the thyroid
  • a rupture in the wall of the stomach or intestine
  • chronic inflammation of muscles in the body called polymyositis
  • inflammation of the white outer coat of the eye
  • pancreatitis
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • multiple organ failure
  • inflammation of the pituitary gland
  • sepsis
  • a type of significant allergic skin reaction called DRESS syndrome
  • histiocytic necrotizing lymphadenitis, a condition with swollen glands in the neck and flu symptoms
  • hemophagocytic lymphohistiocytosis, a condition where the body makes too many activated immune cells
  • Vogt-Koyanagi-Harada disease, an inflammatory disease of certain cells of the eyes, ears and skin
  • inflammation of the colon due to cytomegalovirus infection
  • orbital myositis

If experienced, these tend to have a Less Severe expression i

  • increased eosinophils in the blood
  • pink eye
  • inflammation of the eyelid
  • psoriasis
  • arthritis
  • numbness
  • a feeling of pins and needles on skin
  • peripheral sensory nerve disorder
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.