ZELBORAF Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • squamous cell carcinoma
  • prolonged QT interval on EKG
  • drug or chemical-induced sensitivity to sunlight
  • erythema or redness of skin or mucous membrane
  • fever
  • decreased appetite
  • nausea
  • vomiting
  • diarrhea
  • abnormal liver function tests
  • a type of bumpy skin rash called a maculopapular rash
  • a type of slow growing skin cancer called a keratoacanthoma

If experienced, these tend to have a Less Severe expression i

  • thickening of the outer horny layer of the skin
  • hair loss
  • dry skin
  • joint pain
  • backache
  • muscle pain
  • pain in the arms or legs
  • low energy
  • fluid retention in the legs, feet, arms or hands
  • generalized weakness
  • a small, soft skin growth called cutaneous papilloma

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • inflammation of the blood vessels
  • constipation
  • erythema nodosum, a skin condition with red and painful nodules
  • arthritis
  • erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
  • a hypersensitivity reaction to a drug
  • basal cell carcinoma of the skin

If experienced, these tend to have a Less Severe expression i

  • taste impairment
  • headache
  • pain in the muscles or bones

RARE side effects

If experienced, these tend to have a Severe expression i

  • low levels of a type of white blood cell called neutrophils
  • increased eosinophils in the blood
  • a blockage of blood vessels in the retina of the eye
  • inflammation of the iris - the colored part of the eyeball
  • inflammation of the uvea of the eye
  • atrial fibrillation
  • low blood pressure
  • liver failure
  • inflammation of the liver called hepatitis
  • a type of kidney inflammation called interstitial nephritis
  • renal tubular necrosis, a kidney disorder
  • kidney failure
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • high amount of bilirubin in the blood
  • a significant type of allergic reaction called anaphylaxis
  • a deformity of the hand called a Dupuytren's contracture
  • pancreatitis
  • progression of cancer with the RAS mutation
  • squamous cell carcinoma of mouth
  • radiation sickness
  • a type of significant allergic skin reaction called DRESS syndrome
  • radiation recall syndrome

If experienced, these tend to have a Less Severe expression i

  • visual sensitivity to light
  • blurred vision
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.