Sodium Oxybate/Agents that May Cause Respiratory Depression Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both sodium oxybate and other sedating medicines affect your central nervous system.
What might happen:
You may experience an increase in side effects such as excessive sedation, slowed rate of breathing, confusion, agitation, or loss of coordination.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these medicines together. They may want to change or lower the dose of one or both of your medicines. If you feel very sedated, are sleeping too long at night, experience confusion, agitation, or loss of coordination, contact your doctor.Ask your doctor or pharmacist if you should have naloxone available to treat opioid overdose. Teach your family or household members about the signs of an opioid overdose and how to treat it. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, give them naloxone if available, then call 911. If the person is awake and has no symptoms, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow/shallow breathing, slow heartbeat, coma.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Xyrem (sodium oxybate) US prescribing information. Jazz Pharmaceuticals, Inc. July, 2020.
- 2.USFood and Drug Administration. FDA Drug Safety Communication: Warning against use of Xyrem (sodium oxybate) with alcohol or drugs causing respiratory depression. available at: https://www.fda.gov/Drugs/DrugSafety/ucm332029.htm December 17, 2012.
- 3.USFood and Drug Administration. FDA Drug Safety Communication: FDA recommends health care professionals discuss naloxone with all patients when prescribing opioid pain relievers or medicines to treat opioid use disorder. Available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-recommends-heal th-care-professionals-discuss-naloxone-all-patients-when-prescribing-opioi d-pain July 23, 2020.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.