Armodafinil; Modafinil/Steroidal Contraceptives Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process the steroids in the birth control pills more quickly.

What might happen:

The effects of your birth control pills may decrease and cause breakthrough bleeding, spotting, or pregnancy.

What you should do about this interaction:

Talk to your healthcare professional (e.g. doctor or pharmacist) as soon as possible about using another form of birth control. Contact your doctor if you experience any breakthrough bleeding, spotting, or pregnancy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Provigil (modafinil) UK summary of product characteristics. Cephalon UK Ltd. December 10, 1997.
  • 2.Provigil (modafinil) US prescribing information. Cephalon, Inc. October, 2010.
  • 3.Nuvigil (armodafinil) US prescribing information. Cephalon, Inc. October, 2010.
  • 4.Robertson P Jr, Hellriegel ET, Arora S, Nelson M. Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clin Pharmacol Ther 2002 Jan;71(1):46-56.